Respiratory and dermal exposure to creosote
"The aims of the study were to investigate occupational exposure and the exposure routes of coal tar creosote, and to evaluate the suitability of methods for monitoring occupational exposure to the PAHs in creosote. The composition of four creosotes used in Finland was studied by gas chromatogr...
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| Institution: | ETUI-European Trade Union Institute |
| Format: | TEXT |
| Language: | English |
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Kuopio
2001
University of Kuopio |
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| Online Access: | https://www.labourline.org/KENTIKA-19184478124919026509-Respiratory-and-dermal-exposur.htm |
| Summary: | "The aims of the study were to investigate occupational exposure and the exposure routes of coal tar creosote, and to evaluate the suitability of methods for monitoring occupational exposure to the PAHs in creosote.
The composition of four creosotes used in Finland was studied by gas chromatography/mass spectrometry. Creosotes contain polycyclic aromatic hydrocarbons (over 60%), phenols, and heterocyclic sulphur and nitrogen compounds. The mutagenicity of four creosotes and their chemical fractions was studied with the Ames Salmonella tests. All creosotes were mutagenic with Salmonella typhimurium TA98 in the presence of metabolic activation. The potency of the mutagenicity correlated with the content of benzo(a)pyrene in the creosotes. The mutagenicity of the creosotes was nevertheless higher than that of the distillated fractions containing more BaP than the creosotes.
The kinetics of naphthalene was investigated in two volunteers after intake by oral, dermal and respiratory routes. The kinetic pilot study confirmed that naphthalene is absorbed into the body by all routes in humans, and that the metabolism is route-specific." |
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| Physical Description: | 76 p. Digital |